And unless you have a physician-diagnosed deficiency in any of those nutrients that you just can’t fill with meals alone, there’s no actual must complement at all. “At finest, tremendous-excessive doses of nutrients are shopping for you expensive urine, and at worst, they might contribute to the development of chronic diseases,” she says. While studies show supplementing with excessive doses does help construct muscle mass and enhance energy over time, it’s not pre-workout in the strict sense, in that timing doesn’t really matter. Taking smaller doses extra incessantly through the day might even be an option, but you need to discuss any modifications in your medication timing or dosage with your physician before experimenting by yourself. As an example, a 2017 research in the Journal of Clinical Oncology found that long-time period supplementation with high doses of vitamin B6 and B12 could significantly increase the chance of lung cancer in men